Myeloid-derived suppressor cells: Natural regulators for transplant tolerance

被引：46

作者：

Boros, Peter ^{[1
]}

Ochando, Jordi C. ^{[2
]}

Chen, Shu-Hsia ^{[2
]}

Bromberg, Jonathan S. ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Recanati Miller Transplantat Inst, New York, NY USA

[2] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY USA

来源：

HUMAN IMMUNOLOGY | 2010年 / 71卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Myeloid derived suppressor cells; Organ transplantation; Tolerance; IMMUNE SUPPRESSION; ALLOIMMUNE RESPONSES; CARCINOMA PATIENTS; DENDRITIC CELLS; T-CELLS; CANCER; MECHANISM; EXPANSION; GROWTH; MODULATION;

D O I：

10.1016/j.humimm.2010.08.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid derived suppressor cells (MDSC) contribute to the negative regulation of immune response in cancer patients. This review summarizes results on important issues related to MDSC biology, including expansion and activation of MDSC, phenotype, and subsets as well pathways and different mechanisms by which these cells exert their suppressive effect. Recent observations suggesting that MDSC may have roles in transplant tolerance are presented. Although therapeutic targeting and destruction of MDCS is of primary interest in cancer patients, in transplantation it will instead be necessary to induce, expand, and activate these cells; thus current possibilities for in vitro generation of MDSC are also discussed. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：1061 / 1066

页数：6

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