Drug-metabolizing ability of molybdenum hydroxylases

被引：158

作者：

Kitamura, Shigeyuki ^{[1
]}

Sugihara, Kazumi ^{[1
]}

Ohta, Shigeru ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed Sci, Hiroshima, Japan

来源：

DRUG METABOLISM AND PHARMACOKINETICS | 2006年 / 21卷 / 02期

关键词：

molybdenum hydroxylase; aldehyde oxidase; xanthine oxidoreductase; interindividual variation; drug-drug interaction;

D O I：

10.2133/dmpk.21.83

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Molybdenum hydroxylases, which include aldehyde oxidase and xanthine oxidoreductase, are involved in the metabolism of some medicines in humans. They exhibit oxidase activity towards various heterocyclic compounds and aldehydes. The liver cytosol of various mammals also exhibits a significant reductase activity toward nitro, sulfoxide, N-oxide and other moieties, catalyzed by aldehyde oxidase. There is considerable variability of aldehyde oxidase activity in liver cytosol of mammals: humans show the highest activity, rats and mice show low activity, and dogs have no detectable activity. On the other hand, xanthine oxidoreductase activity is present widely among species. Interindividual variation of aldehyde oxidase activity is present in humans. Drug-drug interactions associated with aldehyde oxidase and xanthine oxidoreductase are of potential clinical significance. Drug metabolizing ability of molybdenum hydroxylases and the variation of the activity are described in this review.

引用

页码：83 / 98

页数：16

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