Poly(ADP-ribosyl)ation in mammalian ageing

被引：80

作者：

Beneke, Sascha ^{[1
]}

Buerkle, Alexander ^{[1
]}

机构：

[1] Univ Konstanz, Dept Biol, Mol Toxicol Grp, D-78457 Constance, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2007年 / 35卷 / 22期

关键词：

D O I：

10.1093/nar/gkm735

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl) ation might act as a factor that limits the rate of ageing.

引用

页码：7456 / 7465

页数：10

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