Structural basis of autoimmunity against G protein coupled membrane receptors

被引：30

作者：

Hoebeke, J

机构：

[1] Equipe d'Immunologic des Recepteurs, CJF93/09 Immunol. Maladies I., Univ. Francois Rabelais, F-37200 Tours, 31, avenue Monge

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 1996年 / 54卷 / 02期

关键词：

G protein coupled membrane receptors; immunogenicity; antigenicity; synthetic peptides; antibodies;

D O I：

10.1016/0167-5273(96)02586-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The structural basis of the function of G protein coupled membrane receptors will be considered taking the beta(2)-adrenergic receptor as model. The immunogenicity and antigenicity of the same receptor will be studied to examine the immunological properties of the G protein coupled membrane receptors. From the two first parts will be derived the conditions which could lead to the building-up of a functional autoimmune response. Finally, the possible application of the structural knowledge on antibody-receptor interactions will be discussed.

引用

页码：103 / 111

页数：9

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