Imposing specificity by localization: mechanism and evolvability

被引：51

作者：

Ptashne, M ^{[1
]}

Gann, A

机构：

[1] Sloan Kettering Canc Inst, Program Mol Biol, New York, NY 10021 USA

[2] Univ Lancaster, Dept Sci Biol, Lancaster LA1 4YQ, England

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 22期

关键词：

D O I：

10.1016/S0960-9822(07)00508-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells detect extracellular signals by allostery and then give those signals meaning by 'regulated localization'. We suggest that this formulation applies to many biological processes and is particularly well illustrated by the mechanisms of gene regulation. Analysis of these mechanisms reveals that regulated localization requires simple molecular interactions that are readily used combinatorially. This system of regulation is highly 'evolvable', and its use accounts, at least in part, for the nature of the complexities observed in biological systems.

引用

页码：R812 / R822

页数：11

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