Association of Human Leukocyte Antigen with Interstitial Lung Disease in Rheumatoid Arthritis: A Protective Role for Shared Epitope

被引：68

作者：

Furukawa, Hiroshi ^{[1
]}

Oka, Shomi ^{[1
]}

Shimada, Kota ^{[2
,3
]}

Sugii, Shoji ^{[2
,3
]}

Ohashi, Jun ^{[4
]}

Matsui, Toshihiro ^{[2
]}

Ikenaka, Tatsuoh ^{[2
]}

Nakayama, Hisanori ^{[2
]}

Hashimoto, Atsushi ^{[2
]}

Takaoka, Hirokazu ^{[2
]}

Arinuma, Yoshiyuki ^{[2
]}

Okazaki, Yuko ^{[2
]}

Futami, Hidekazu ^{[2
]}

Komiya, Akiko ^{[1
]}

Fukui, Naoshi ^{[1
]}

Nakamura, Tadashi ^{[5
]}

Migita, Kiyoshi ^{[6
]}

Suda, Akiko ^{[7
]}

Nagaoka, Shouhei ^{[7
]}

Tsuchiya, Naoyuki ^{[4
]}

Tohma, Shigeto ^{[1
]}

机构：

[1] Natl Hosp Org, Sagamihara Hosp, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan

[2] Natl Hosp Org, Sagamihara Hosp, Dept Rheumatol, Sagamihara, Kanagawa, Japan

[3] Tokyo Metropolitan Tama Med Ctr, Fuchu, Tokyo, Japan

[4] Univ Tsukuba, Fac Med, Mol & Genet Epidemiol Lab, Tsukuba, Ibaraki, Japan

[5] Kumamoto Ctr Arthrit & Rheumatol, Kumamoto, Japan

[6] Natl Hosp Org, Nagasaki Med Ctr, Omura, Japan

[7] Yokohama Minami Kyosai Hosp, Dept Rheumatol, Kanazawa Ku, Yokohama, Kanagawa, Japan

来源：

PLOS ONE | 2012年 / 7卷 / 05期

基金：

日本学术振兴会;

关键词：

EXTRAARTICULAR MANIFESTATIONS; HAPLOTYPE RECONSTRUCTION; PULMONARY-FIBROSIS; JAPANESE PATIENTS; HLA-DRB1-ASTERISK-15; COMPLEX; IMPACT; GENES;

D O I：

10.1371/journal.pone.0033133

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Introduction: Interstitial Lung Disease (ILD) is frequently associated with Rheumatoid Arthritis (RA) as one of extra-articularmanifestations. Many studies for Human Leukocyte Antigen (HLA) allelic association with RA have been reported, but few have been validated in an RA subpopulation with ILD. In this study, we investigated the association of HLA class II alleles with ILD in RA. Methods: An association study was conducted on HLA-DRB1, DQB1, and DPB1 in 450 Japanese RA patients that were or were not diagnosed with ILD, based on the findings of computed tomography images of the chest. Results: Unexpectedly, HLA-DRB1*04 (corrected P [Pc] = 0.0054, odds ratio [OR] 0.57), shared epitope (SE) (P = 0.0055, OR 0.66) and DQB1*04 (Pc = 0.0036, OR 0.57) were associated with significantly decreased risk of ILD. In contrast, DRB1*16 (Pc = 0.0372, OR 15.21), DR2 serological group (DRB1*15 and *16 alleles) (P = 0.0020, OR 1.75) and DQB1*06 (Pc = 0.0333, OR 1.57, respectively) were significantly associated with risk of ILD. Conclusion: HLA-DRB1 SE was associated with reduced, while DR2 serological group (DRB1*15 and *16) with increased, risk for ILD in Japanese patients with RA.

引用

页数：7

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