A critical appraisal of the hemodynamic signal driving liver regeneration

被引：69

作者：

Abshagen, Kerstin ^{[1
]}

Eipel, Christian ^{[1
]}

Vollmar, Brigitte ^{[1
]}

机构：

[1] Univ Rostock, Inst Expt Surg, D-18055 Rostock, Germany

来源：

LANGENBECKS ARCHIVES OF SURGERY | 2012年 / 397卷 / 04期

关键词：

Liver regeneration; Partial hepatectomy; Shear stress; Microcirculation; Hepatic arterial buffer response; Blood-flow theory; ARTERIAL BUFFER RESPONSE; PORTAL-VEIN EMBOLIZATION; NITRIC-OXIDE SYNTHASE; HEPATIC BLOOD-FLOW; SHEAR-STRESS; PARTIAL-HEPATECTOMY; RAT-LIVER; KAPPA-B; HEPATOCYTE PROLIFERATION; MOLECULAR-MECHANISMS;

D O I：

10.1007/s00423-012-0913-0

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Many aspects of the signaling mechanisms involved in the initiation of hepatic regeneration are under current investigation. Nevertheless, the actual mechanisms switching liver regeneration on and off are still unknown. Hemodynamic changes in the liver following partial hepatectomy have been suggested to be a primary stimulus in triggering liver regeneration. Most of the new knowledge about the impact of hemodynamic changes on liver regeneration is both conceptually important and directly relevant to clinical problems. The purpose of this review is therefore to exclusively address the hemodynamic signal driving the liver regeneration process.

引用

页码：579 / 590

页数：12

共 135 条

[1]

Kupffer cells are mandatory for adequate liver regeneration by mediating hyperperfusion via modulation of vasoactive proteins [J].