UDP-GlcNAc 2-epimerase: A regulator of cell surface sialylation

被引：277

作者：

Keppler, OT

Hinderlich, S

Langner, J

Schwartz-Albiez, R

Reutter, W

Pawlita, M

机构：

[1] Deutsch Krebsforschungszentrum, Appl Tumor Virol Program, D-69120 Heidelberg, Germany

[2] Free Univ Berlin, Inst Mol Biol & Biochem, D-14195 Berlin, Germany

来源：

SCIENCE | 1999年 / 284卷 / 5418期

关键词：

D O I：

10.1126/science.284.5418.1372

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction, Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GLcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell Lines and a critical regulator of the function of specific cell surface adhesion molecules.

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页码：1372 / 1376

页数：5

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