PI 3-kinase, mTOR, protein synthesis and cancer

被引：117

作者：

Vogt, PK ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 11期

关键词：

D O I：

10.1016/S1471-4914(01)02161-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mTOR kinase is an essential mediator of growth signals that originate from PI 3-kinase. Downstream targets of mTOR, p70 S6 kinase and 4E binding protein are important regulators of protein synthesis. Inhibition of mTOR by rapamycin interferes with oncogenic transformation and with tumor development by gain-of-function in PI 3-kinase signaling.

引用

页码：482 / 484

页数：3

共 21 条

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