Exaggerated serotonin-mediated platelet reactivity as a possible link in depression and acute coronary syndromes

被引：85

作者：

Shimbo, D

Child, J

Davidson, K

Geer, E

Osende, JI

Reddy, S

Dronge, A

Fuster, V

Badimon, JJ

机构：

[1] Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, Cardiovasc Biol Res Lab, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Div Gen Internal Med, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 89卷 / 03期

关键词：

D O I：

10.1016/S0002-9149(01)02236-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Depressive illness increases the risk of first acute coronary syndrome events, but the underlying mechanisms remain undetermined. Our finding that serotonin-mediated platelet reactivity was significantly higher in depressed patients relative to nondepressed controls suggests that the association between depression and acute coronar), syndromes is related to increased serotonin-mediated platelet reactivity.

引用

页码：331 / +

页数：4

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