Size at birth, adult intestinal calcium absorption and 1,25(OH)2 vitamin D

被引:11
作者
Arden, NK
Major, P
Poole, JR
Keen, RW
Vaja, S
Swaminathan, R
Cooper, C
Spector, TD
机构
[1] Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England
[2] St Thomas Hosp, Twin Res & Genet Epidemiol Unit, London SE1 7EH, England
[3] St Thomas Hosp, Dept Chem Pathol, London SE1 7EH, England
基金
英国惠康基金;
关键词
D O I
10.1093/qjmed/95.1.15
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Adult bone mineral status is modified by early environmental influences, but the mechanism of this phenomenon is unknown. Intestinal calcium absorption and vitamin D metabolism are integrally involved in bone metabolism and may be programmed during early life. Aim: To examine the early-life influences on calcium absorption and its control in 322 post-menopausal female twins. Methods: Intestinal calcium absorption was assessed by the stable strontium (Sr) method. Serum PTH, 25(OH) and 1,25(OH)(2) vitamin D were measured and recalled birth weight recorded. Results: Fractional intestinal Sr absorption (alphaSr) was correlated with serum 1,25(OH)(2) vitamin D (p < 0.001), but not with 25(OH) vitamin D. Birth weight was inversely associated with serum 1,25(OH)(2) vitamin D (p = 0.04), the association being independent of serum calcium, phosphate, creatinine and PTH. Birth weight was inversely correlated with alphaSr (p = 0.03), this association being independent of age, season, customary calcium intake and serum 25(OH) vitamin D; however, when serum 1,25(OH)(2) vitamin D was added into the model, the association became non-significant, suggesting that the association was partially mediated via serum 1,25(OH)(2) vitamin D. Discussion: We found a significant inverse association between birth weight and intestinal calcium absorption that is partially explained by an association between serum 1,25(OH)(2) vitamin D and birth weight. This suggests a mechanism whereby the intra-uterine environment might affect adult skeletal status.
引用
收藏
页码:15 / 21
页数:7
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