Exosome-Mediated Metastasis: Communication from a Distance

被引：1279

作者：

Wortzel, Inbal ^{[1
,2
]}

Dror, Shani ^{[1
,2
]}

Kenific, Candia M. ^{[1
,2
]}

Lyden, David ^{[1
,2
]}

机构：

[1] Weill Cornell Med, Drukier Inst Childrens Hlth, Childrens Canc & Blood Fdn Labs, Dept Pediat,Meyer Canc Ctr, New York, NY 10021 USA

[2] Weill Cornell Med, Drukier Inst Childrens Hlth, Childrens Canc & Blood Fdn Labs, Dept Cell & Dev Biol,Meyer Canc Ctr, New York, NY 10021 USA

来源：

DEVELOPMENTAL CELL | 2019年 / 49卷 / 03期

关键词：

MINIMALLY INVASIVE BIOMARKER; CELL-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; CANCER-CELLS; TISSUE FACTOR; INTERCELLULAR COMMUNICATION; PLASMA-MEMBRANE; NICHE FORMATION; TUMOR-CELLS; MUTANT KRAS;

D O I：

10.1016/j.devcel.2019.04.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes.

引用

页码：347 / 360

页数：14

共 144 条

[1]

Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Micallef, Johann ;

Lhotak, Vladimir ;

May, Linda ;

Guha, Abhijit ;

Rak, Janusz .

NATURE CELL BIOLOGY, 2008, 10 (05) :619-U24

[2]

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Kerbel, Robert S. ;

Allison, Anthony C. ;

Rak, Janusz .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (10) :3794-3799

[3]

High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients [J].

Allenson, K. ;

Castillo, J. ;

San Lucas, F. A. ;

Scelo, G. ;

Kim, D. U. ;

Bernard, V. ;

Davis, G. ;

Kumar, T. ;

Katz, M. ;

Overman, M. J. ;

Foretova, L. ;

Fabianova, E. ;

Holcatova, I. ;

Janout, V. ;

Meric-Bernstam, F. ;

Gascoyne, P. ;

Wistuba, I. ;

Varadhachary, G. ;

Brennan, P. ;

Hanash, S. ;

Li, D. ;

Maitra, A. ;

Alvarez, H. .

ANNALS OF ONCOLOGY, 2017, 28 (04) :741-747

[4]

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[5]

[Anonymous], 2018, MOL CANCER

[6]

Antonyak MA, 2014, METHODS MOL BIOL, V1165, P147, DOI 10.1007/978-1-4939-0856-1_11

[7]

Chromosomal instability drives metastasis through a cytosolic DNA response [J].

Bakhoum, Samuel F. ;

Ngo, Bryan ;

Laughney, Ashley M. ;

Cavallo, Julie-Ann ;

Murphy, Charles J. ;

Ly, Peter ;

Shah, Pragya ;

Sriram, Roshan K. ;

Watkins, Thomas B. K. ;

Taunk, Neil K. ;

Duran, Mercedes ;

Pauli, Chantal ;

Shaw, Christine ;

Chadalavada, Kalyani ;

Rajasekhar, Vinagolu K. ;

Genovese, Giulio ;

Venkatesan, Subramanian ;

Birkbak, Nicolai J. ;

McGranahan, Nicholas ;

Lundquist, Mark ;

LaPlant, Quincey ;

Healey, John H. ;

Elemento, Olivier ;

Chung, Christine H. ;

Lee, Nancy Y. ;

Imielenski, Marcin ;

Nanjangud, Gouri ;

Pe'er, Dana ;

Cleveland, Don W. ;

Powell, Simon N. ;

Lammerding, Jan ;

Swanton, Charles ;

Cantley, Lewis C. .

NATURE, 2018, 553 (7689) :467-+

[8]

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences [J].

Balaj, Leonora ;

Lessard, Ryan ;

Dai, Lixin ;

Cho, Yoon-Jae ;

Pomeroy, Scott L. ;

Breakefield, Xandra O. ;

Skog, Johan .

NATURE COMMUNICATIONS, 2011, 2

[9]

Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior [J].

Bandari, Shyam K. ;

Purushothaman, Anurag ;

Ramani, Vishnu C. ;

Brinkley, Garrett J. ;

Chandrashekar, Darshan S. ;

Varambally, Sooryanarayana ;

Mobley, James A. ;

Zhang, Yi ;

Brown, Elizabeth E. ;

Vlodavsky, Israel ;

Sanderson, Ralph D. .

MATRIX BIOLOGY, 2018, 65 :104-118

[10]

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells [J].

Bebawy, M. ;

Combes, V. ;

Lee, E. ;

Jaiswal, R. ;

Gong, J. ;

Bonhoure, A. ;

Grau, G. E. R. .

LEUKEMIA, 2009, 23 (09) :1643-1649

← 1 2 3 4 5 6 7 8 9 10 →