Application of NT-proBNP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure

被引：169

作者：

Seino, Y ^{[1
]}

Ogawa, A ^{[1
]}

Yamashita, T ^{[1
]}

Fukushima, M ^{[1
]}

Ogata, K ^{[1
]}

Fukumoto, H ^{[1
]}

Takano, T ^{[1
]}

机构：

[1] Nippon Med Coll, Dept Internal Med 1, Tokyo 113, Japan

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2004年 / 6卷 / 03期

关键词：

heart failure; brain natriuretic peptide; left ventricular ejection fraction; acute coronary syndrome; hypertensive heart disease;

D O I：

10.1016/j.ejheart.2003.12.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Measurement of brain natriuretic peptide (BNP) has become a potent diagnostic aid as a means of identifying patients with systolic or diastolic dysfunction. Due to better stability in circulating blood, we reasoned that measurement of N-termimal proBNP (NT-proBNP) may be a more discerning marker for the detection and evaluation of chronic heart failure. Methods: The relationships between plasma concentrations of NT-proBNP and BNP, and actiology, New York Heart Association (NYHA) classification, and left ventricular ejection fraction (LVEF) were analyzed in 105 patients with chronic heart failure. Sixty-seven healthy volunteers were studied as the controls. Results: Both NT-proBNP and BNP showed progressive increases (P<0.001) in proportion to the NYHA classification; the increment of NT-proBNP was larger than that of BNR Elevated NT-proBNP significantly correlated with BNP (r=0.737, P<0.001). Receiver operating characteristics analysis to detect LVEF<40% showed similar values (area under the curve, AUC: NT-proBNP 0.754 vs. BNP 0.770), however, AUC to detect LVEF<50% tended to be greater for NT-proBNP than that for BNP (NT-proBNP 0.820 vs. BNP 0.794). Conclusion: NT-proBNP may be a more discerning marker for the detection and evaluation of heart failure than BNP. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：295 / 300

页数：6

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