Implications of antiretroviral resistance on viral fitness

被引：143

作者：

Nijhuis, M ^{[1
]}

Deeks, S ^{[1
]}

Boucher, C ^{[1
]}

机构：

[1] Univ Med Ctr, Dept Virol, Eijkman Winkler Inst, NL-3584 CX Utrecht, Netherlands

来源：

CURRENT OPINION IN INFECTIOUS DISEASES | 2001年 / 14卷 / 01期

关键词：

D O I：

10.1097/00001432-200102000-00005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Treatment of HIV infected patients with antiretroviral drugs often results in the emergence of virus variants with reduced sensitivity to these drugs. However, the viral load often remains partially suppressed below pretherapy levels, which might be explained by a reduced fitness of the drug resistant viral population. This review describes the effects of antiretroviral resistance development on the fitness of the viral population and its clinical implications. Curr Opin Infect Dis 14:23-28. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：23 / 28

页数：6

共 50 条

[1] PERSISTENCE OF AZIDOTHYMIDINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA GENOTYPES IN POSTTREATMENT SERA [J].

ALBERT, J ;

WAHLBERG, J ;

LUNDEBERG, J ;

COX, S ;

SANDSTROM, E ;

WAHREN, B ;

UHLEN, M .

JOURNAL OF VIROLOGY, 1992, 66 (09) :5627-5630

[2] Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme [J].

Back, NKT ;

Nijhuis, M ;

Keulen, W ;

Boucher, CAB ;

Essink, BBO ;

vanKuilenburg, ABP ;

vanGennip, AH ;

Berkhout, B .

EMBO JOURNAL, 1996, 15 (15) :4040-4049

[3]

BECKERPERGOLA G, 2000, 7 C RETR OPP INF JAN

[4] Resistance of human immunodeficiency virus type 1 to protease inhibitors: Selection of resistance mutations in the presence and absence of the drug [J].

Borman, AM ;

Paulous, S ;

Clavel, F .

JOURNAL OF GENERAL VIROLOGY, 1996, 77 :419-426

[5] ORDERED APPEARANCE OF ZIDOVUDINE RESISTANCE MUTATIONS DURING TREATMENT OF 18 HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE SUBJECTS [J].

BOUCHER, CAB ;

OSULLIVAN, E ;

MULDER, JW ;

RAMAUTARSING, C ;

KELLAM, P ;

DARBY, G ;

LANGE, JMA ;

GOUDSMIT, J ;

LARDER, BA .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (01) :105-110

[6] EFFECTS OF DISCONTINUATION OF ZIDOVUDINE TREATMENT ON ZIDOVUDINE SENSITIVITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES [J].

BOUCHER, CAB ;

VANLEEUWEN, R ;

KELLAM, P ;

SCHIPPER, P ;

TIJNAGEL, J ;

LANGE, JMA ;

LARDER, BA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (07) :1525-1530

[7] EVOLUTION OF A BACTERIA PLASMID ASSOCIATION [J].

BOUMA, JE ;

LENSKI, RE .

NATURE, 1988, 335 (6188) :351-352

[8] Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication [J].

Caliendo, AM ;

Savara, A ;

An, D ;

DeVore, K ;

Kaplan, JC ;

DAquila, RT .

JOURNAL OF VIROLOGY, 1996, 70 (04) :2146-2153

[9] Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors [J].

Croteau, G ;

Doyon, L ;

Thibeault, D ;

McKercher, G ;

Pilote, L ;

Lamarre, D .

JOURNAL OF VIROLOGY, 1997, 71 (02) :1089-1096

[10]

DEEKS S, 2000, P 4 INT WORKSH HIV D

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