The STEP Study Provides a Hint That Vaccine Induction of the Right CD8+ T Cell Responses Can Facilitate Immune Control of HIV

被引:9
作者
Altfeld, Marcus [2 ]
Goulder, Philip J. [1 ]
机构
[1] Univ Oxford, Dept Paediat, Oxford, England
[2] Ragon Inst Massachusetts Gen Hosp Massachusetts I, Boston, MA USA
关键词
IMMUNODEFICIENCY VIRUS-REPLICATION; RHESUS-MONKEYS; VIRAL LOAD; CLASS-I; ESCAPE; TRANSMISSION; CHALLENGE; INFECTION; EXPANSION; FAILURE;
D O I
10.1093/infdis/jiq119
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:753 / 755
页数:3
相关论文
共 30 条
  • [1] Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Altfeld, M
    Addo, MA
    Rosenberg, ES
    Hecht, FA
    Lee, PK
    Vogel, M
    Yu, XG
    Draenert, R
    Johnston, MN
    Strick, D
    Allen, TA
    Feeney, ME
    Kahn, JO
    Sekaly, RP
    Levy, JA
    Rockstroh, JK
    Goulder, PJR
    Walker, BD
    [J]. AIDS, 2003, 17 (18) : 2581 - 2591
  • [2] HLA alleles associated with delayed progression to AIDS contribute strongly to the initial CD8+ T cell response against HIV-1
    Altfeld, Marcus
    Kalife, Elizabeth T.
    Qi, Ying
    Streeck, Hendrik
    Lichterfeld, Mathias
    Johnston, Mary N.
    Burgett, Nicole
    Swartz, Martha E.
    Yang, Amy
    Alter, Galit
    Yu, Xu G.
    Meier, Angela
    Rockstroh, Juergen K.
    Allen, Todd M.
    Jessen, Heiko
    Rosenberg, Eric S.
    Carrington, Mary
    Walker, Bruce D.
    [J]. PLOS MEDICINE, 2006, 3 (10) : 1851 - 1864
  • [3] Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
    Barouch, Dan H.
    O'Brien, Kara L.
    Simmons, Nathaniel L.
    King, Sharon L.
    Abbink, Peter
    Maxfield, Lori F.
    Sun, Ying-Hua
    La Porte, Annalena
    Riggs, Ambryice M.
    Lynch, Diana M.
    Clark, Sarah L.
    Backus, Katherine
    Perry, James R.
    Seaman, Michael S.
    Carville, Angela
    Mansfield, Keith G.
    Szinger, James J.
    Fischer, Will
    Muldoon, Mark
    Korber, Bette
    [J]. NATURE MEDICINE, 2010, 16 (03) : 319 - U116
  • [4] HIV-1 Vaccine Development After STEP
    Barouch, Dan H.
    Korber, Bette
    [J]. ANNUAL REVIEW OF MEDICINE, 2010, 61 : 153 - 167
  • [5] Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1
    Benlahrech, Adel
    Harris, Julian
    Meiser, Andrea
    Papagatsias, Timos
    Hornig, Julia
    Hayes, Peter
    Lieber, Andre
    Athanasopoulos, Takis
    Bachy, Veronique
    Csomor, Eszter
    Daniels, Rod
    Fisher, Kerry
    Gotch, Frances
    Seymour, Len
    Logan, Karen
    Barbagallo, Romina
    Klavinskis, Linda
    Dickson, George
    Patterson, Steven
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (47) : 19940 - 19945
  • [6] Escape and compensation from early HLA-B57-Mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A
    Brockman, Mark A.
    Schneidewind, Arne
    Lahaie, Matthew
    Schmidt, Aaron
    Miura, Toshiyuki
    DeSouza, Ivna
    Ryvkin, Faina
    Derdeyn, Cynthia A.
    Allen, Susan
    Hunter, Eric
    Mulenga, Joseph
    Goepfert, Paul A.
    Walker, Bruce D.
    Allen, Todd M.
    [J]. JOURNAL OF VIROLOGY, 2007, 81 (22) : 12608 - 12618
  • [7] Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
    Buchbinder, Susan P.
    Mehrotra, Devon V.
    Duerr, Ann
    Fitzgerald, Daniel W.
    Mogg, Robin
    Li, David
    Gilbert, Peter B.
    Lama, Javier R.
    Marmor, Michael
    del Rio, Carlos
    McElrath, M. Juliana
    Casimiro, Danilo R.
    Gottesdiener, Keith M.
    Chodakewitz, Jeffrey A.
    Corey, Lawrence
    Robertson, Michael N.
    [J]. LANCET, 2008, 372 (9653) : 1881 - 1893
  • [8] Post-Step modifications for research on HIV vaccines
    Corey, Lawrence
    McElrath, M. Juliana
    Kublin, James G.
    [J]. AIDS, 2009, 23 (01) : 3 - 8
  • [9] Common Genetic Variation and the Control of HIV-1 in Humans
    Fellay, Jacques
    Ge, Dongliang
    Shianna, Kevin V.
    Colombo, Sara
    Ledergerber, Bruno
    Cirulli, Elizabeth T.
    Urban, Thomas J.
    Zhang, Kunlin
    Gumbs, Curtis E.
    Smith, Jason P.
    Castagna, Antonella
    Cozzi-Lepri, Alessandro
    De Luca, Andrea
    Easterbrook, Philippa
    Guenthard, Huldrych F.
    Mallal, Simon
    Mussini, Cristina
    Dalmau, Judith
    Martinez-Picado, Javier
    Miro, Jose M.
    Obel, Niels
    Wolinsky, Steven M.
    Martinson, Jeremy J.
    Detels, Roger
    Margolick, Joseph B.
    Jacobson, Lisa P.
    Descombes, Patrick
    Antonarakis, Stylianos E.
    Beckmann, Jacques S.
    O'Brien, Stephen J.
    Letvin, Norman L.
    McMichael, Andrew J.
    Haynes, Barton F.
    Carrington, Mary
    Feng, Sheng
    Telenti, Amalio
    Goldstein, David B.
    [J]. PLOS GENETICS, 2009, 5 (12):
  • [10] Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
    Goepfert, Paul A.
    Lumm, Wendy
    Farmer, Paul
    Matthews, Philippa
    Prendergast, Andrew
    Carlson, Jonathan M.
    Derdeyn, Cynthia A.
    Tang, Jianming
    Kaslow, Richard A.
    Bansal, Anju
    Yusim, Karina
    Heckerman, David
    Mulenga, Joseph
    Allen, Susan
    Goulder, Philip J. R.
    Hunter, Eric
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (05) : 1009 - 1017