Coxsackievirus-mediated hyperglycemia is enhanced by reinfection and this occurs independent of T cells

被引:19
作者
Horwitz, MS
Ilic, A
Fine, C
Rodriguez, E
Sarvetnick, N
机构
[1] Scripps Res Inst, Dept Immunol IMM 23, La Jolla, CA 92037 USA
[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 123, Canada
关键词
insulin-dependent diabetes mellitus; coxsackievirus; T lymphocytes;
D O I
10.1016/S0042-6822(03)00462-8
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The induction of autoimmunity by viruses has been hypothesized to occur by a number of mechanisms. Coxsackievirus 134 (CB4) induces hyperglycemia in SJL mice resembling diabetes in humans. While virus is effectively cleared within 2 weeks, hyperglycemia does not appear until about 8-12 weeks postinfection at a time when replicative virus is no longer detectable. In SJL mice, reinfection with CB4 enhanced the development of hyperglycemia. As predicted, the immune system responded more rapidly to the second infection and virus was cleared more swiftly. However, while infiltrating T cells were found within the pancreas, depletion of the CD4 T cell population prior to secondary infection or use of CD8 knock-out mice had no effect on the development of virus-mediated hyperglycemia. In conclusion, enhanced hyperglycemia induced by CB4 occurs independent of the T cell response. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:510 / 520
页数:11
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