Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy

被引：1099

作者：

Gobin, Andre M.

Lee, Min Ho

Halas, Naomi J.

James, William D.

Drezek, Rebekah A.

West, Jennifer L.

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[2] Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA

[3] Texas A&M Univ, Ctr Chem Characterizat & Anal, College Stn, TX 77843 USA

来源：

NANO LETTERS | 2007年 / 7卷 / 07期

关键词：

COHERENCE TOMOGRAPHY; CONTRAST AGENTS; NANOTECHNOLOGY; BIOPSY;

D O I：

10.1021/nl070610y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metal nanoshells are core/shell nanoparticles that can be designed to either strongly absorb or scatter within the near-infrared (NIR) wavelength region (similar to 650-950 nm). Nanoshells were designed that possess both absorption and scattering properties in the NIR to provide optical contrast for improved diagnostic imaging and, at higher light intensity, rapid heating for photothermal therapy. Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors.

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页码：1929 / 1934

页数：6

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