A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

被引：1302

作者：

Yang, XJ ^{[1
]}

Ogryzko, VV ^{[1
]}

Nishikawa, J ^{[1
]}

Howard, BH ^{[1
]}

Nakatani, Y ^{[1
]}

机构：

[1] NICHHD,LAB MOL GROWTH REGULAT,NIH,BETHESDA,MD 20892

来源：

NATURE | 1996年 / 382卷 / 6589期

关键词：

D O I：

10.1038/382319a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.

引用

页码：319 / 324

页数：6

共 36 条

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