SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging

被引：68

作者：

Blum, Charles A. ^{[1
]}

Ellis, James L. ^{[1
]}

Loh, Christine ^{[1
]}

Ng, Pui Yee ^{[1
]}

Perni, Robert B. ^{[1
]}

Stein, Ross L. ^{[1
]}

机构：

[1] Sirtris, Cambridge, MA 02139 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 02期

关键词：

NAD(+)-DEPENDENT HISTONE DEACETYLASES; STIMULATED INSULIN-SECRETION; EPSILON-THIOACETYL-LYSINE; SMALL-MOLECULE ACTIVATORS; REPLICATIVE LIFE-SPAN; MITOCHONDRIAL BIOGENESIS; SUBSTRATE-SPECIFICITY; OXIDATIVE STRESS; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS;

D O I：

10.1021/jm100861p

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

收藏

页码：417 / 432

页数：16

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