Pd-catalyzed dynamic kinetic enantioselective arylation of silylphosphines

被引：124

作者：

Chan, Vincent S. ^{[1
]}

Bergman, Robert G. ^{[1
]}

Toste, F. Dean ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 49期

关键词：

D O I：

10.1021/ja076457r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium-catalyzed cross-couplings represent a powerful method for the formatioil of new bonds. A catalytic, enantioselective P-C bond-forming reaction proceeding via a Pd-mediated arylation of silylphosphines was developed for the synthesis of P-stereogenic phosphines. These useful and synthetically challenging phosphines can be made with a variety of functionalized aryl iodides; however, they proceed most enantioselectively with 2-iodo-N ,N -diisopropylbenzamides.

引用

页码：15122 / +

页数：3

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