A Chlamydia pneumoniae-specific peptide induces experimental autoimmune encephalomyelitis in rats

被引:55
作者
Lenz, DC
Lu, L
Conant, SB
Wolf, NA
Gérard, HC
Whittum-Hudson, JA
Hudson, AP
Swanborg, RH
机构
[1] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA
[2] Wayne State Univ, Sch Med, Dept Internal Med, Detroit, MI 48201 USA
[3] Wayne State Univ, Sch Med, Dept Ophthalmol, Detroit, MI 48201 USA
关键词
D O I
10.4049/jimmunol.167.3.1803
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It has been reported recently that the bacterial respiratory pathogen Chlamydia pneumoniae is present in the cerebrospinal fluid of a subset of multiple sclerosis (MS) patients. However, it is not known whether this organism is a causative agent of MS, or merely an opportunistic pathogen that takes advantage of a disease process initiated by some other means. We report identification of a 20-mer peptide from a protein specific to C. pneumoniae which shares a 7-aa motif with a critical epitope of myelin basic protein, a major CNS Ag targeted by the autoimmune response in MS. This bacterial peptide induces a Th1 response accompanied by severe clinical and histological experimental autoimmune encephalomyelitis in Lewis rats, a condition closely reflective of many aspects of MS. Studies with peptide analogues suggest that different populations of encephalitogenic T cells are activated by the C. pneumoniae and myelin basic protein Ags. Mild experimental autoimmune encephalomyelitis was also observed when rats were immunized with sonicated C. pneumoniae in CFA.
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页码:1803 / 1808
页数:6
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