Biological simulations in drug discovery

被引:36
作者
Noble, D
Levin, J
Scott, W
机构
[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England
[2] Physiome Sci, Princeton, NJ USA
关键词
D O I
10.1016/S1359-6446(98)01277-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Simulation of biological processes, systems and organs is a necessary complement to genetic and molecular sequencing. Using the heart as an example, the authors describe the way in which such modelling can be used in drug discovery, development and assessment. The technology is readily applicable to other organs and systems as well; models of neurones and neuronal systems, the pancreas and the lungs have already been developed. Ultimately, a virtual corpus is feasible.
引用
收藏
页码:10 / 16
页数:7
相关论文
共 47 条
[1]  
[Anonymous], 1989, NEW ENGL J MED, V321, P406
[2]  
Brenner S, 1998, CIBA F SYMP, V213, P106
[3]   THEORETICAL RECONSTRUCTION OF MYOTONIA AND PARALYSIS CAUSED BY INCOMPLETE INACTIVATION OF SODIUM-CHANNELS [J].
CANNON, SC ;
BROWN, RH ;
COREY, DP .
BIOPHYSICAL JOURNAL, 1993, 65 (01) :270-288
[4]   Modelling myocardial ischaemia and reperfusion [J].
Ch'en, FFT ;
Vaughan-Jones, RD ;
Clarke, K ;
Noble, D .
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1998, 69 (2-3) :515-538
[5]   Modeling slowly bursting neurons via calcium store and voltage-independent calcium current [J].
Chay, TR .
NEURAL COMPUTATION, 1996, 8 (05) :951-978
[6]   Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells [J].
Chay, TR .
BIOPHYSICAL JOURNAL, 1997, 73 (03) :1673-1688
[7]   Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model [J].
Courtemanche, M ;
Ramirez, RJ ;
Nattel, S .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1998, 275 (01) :H301-H321
[8]   MODELING RECEPTOR-CONTROLLED INTRACELLULAR CALCIUM OSCILLATORS [J].
CUTHBERTSON, KSR ;
CHAY, TR .
CELL CALCIUM, 1991, 12 (2-3) :97-109
[9]   A MATHEMATICAL-MODEL OF A RABBIT SINOATRIAL NODE CELL [J].
DEMIR, SS ;
CLARK, JW ;
MURPHEY, CR ;
GILES, WR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (03) :C832-C852
[10]   A MODEL OF CARDIAC ELECTRICAL-ACTIVITY INCORPORATING IONIC PUMPS AND CONCENTRATION CHANGES [J].
DIFRANCESCO, D ;
NOBLE, D .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1985, 307 (1133) :353-398