Ion Channels in the Heart

被引：132

作者：

Bartos, Daniel C. ^{[1
]}

Grandi, Eleonora ^{[1
]}

Ripplinger, Crystal M. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USA

来源：

COMPREHENSIVE PHYSIOLOGY | 2015年 / 5卷 / 03期

基金：

美国国家卫生研究院;

关键词：

TRANSIENT OUTWARD CURRENT; LONG-QT SYNDROME; RECTIFIER POTASSIUM CURRENT; PROTEIN-KINASE-A; SARCOPLASMIC-RETICULUM CA2+; HUMAN VENTRICULAR MYOCYTES; RABBIT SINOATRIAL NODE; OF-FUNCTION MUTATION; RYANODINE RECEPTOR PHOSPHORYLATION; CHRONIC ATRIAL-FIBRILLATION;

D O I：

10.1002/cphy.c140069

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Optimal cardiac function depends on proper timing of excitation and contraction in various regions of the heart, as well as on appropriate heart rate. This is accomplished via specialized electrical properties of various components of the system, including the sinoatrial node, atria, atrioventricular node, His-Purkinje system, and ventricles. Here we review the major regionally determined electrical properties of these cardiac regions and present the available data regarding the molecular and ionic bases of regional cardiac function and dysfunction. Understanding these differences is of fundamental importance for the investigation of arrhythmia mechanisms and pharmacotherapy. (C) 2015 American Physiological Society.

引用

页码：1423 / 1464

页数：42

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