NGAL is a Precocious Marker of Therapeutic Response

被引:20
作者
Cernaro, Valeria [1 ]
Bolignano, Davide [1 ]
Donato, Valentina [1 ]
Lacquaniti, Antonio [1 ]
Buemi, Antoine [1 ]
Crasci, Eleonora [1 ]
Lucisano, Silvia [1 ]
Buemi, Michele [1 ]
机构
[1] Univ Messina, Dept Internal Med, Messina, Italy
关键词
NGAL; acute renal failure; chronic kidney disease; clinical nephrology; clinical pharmacology; GELATINASE-ASSOCIATED LIPOCALIN; PROTEINURIC PATIENTS; ULCERATIVE-COLITIS; EPITHELIAL-CELLS; EARLY BIOMARKER; KIDNEY-DISEASE; RENAL-FUNCTION; INJURY; NEPHROPATHY; DAMAGE;
D O I
10.2174/138161211795428939
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
NGAL (Neutrophil Gelatinase-Associated Lipocalin) is a small 25-kD peptide belonging to the lipocalin superfamily. Several studies highlight its role as an organ injury and disease activity biomarker. In the present review, instead, we wanted to study NGAL as a precocious marker of therapeutic response in renal and non-renal diseases (glomerulonephritis, vasculitis, LES, Crohn's disease and other chronic inflammatory pathologies). The obtained outcomes support the hypothesis that NGAL could be employed as a biomarker of response to different therapeutic schemes, because its levels sensibly and precociously change compared to other haematologic and biochemical parameters.
引用
收藏
页码:844 / 849
页数:6
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