Copper-Catalyzed Cross-Coupling of Functionalized Alkyl Halides and Tosylates with Secondary and Tertiary Alkyl Grignard Reagents

被引：89

作者：

Ren, Peng ^{[1
]}

Stern, Lucas-Alexandre ^{[1
]}

Hu, Xile ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Inorgan Synth & Catalysis, Inst Chem Sci & Engn, ISIC LSCI, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 36期

基金：

瑞士国家科学基金会;

关键词：

alkylation; copper; cross-coupling; Grignard reaction; homogeneous catalysis; NICKEL PINCER COMPLEX; SP(3) CARBON CENTERS; ROOM-TEMPERATURE; ARYL BROMIDES; ELECTROPHILES; PSEUDOHALIDES; NI; PD; NUCLEOPHILES; CHLORIDES;

D O I：

10.1002/anie.201204275

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Added value: A copper-based method is highly efficient for the cross-coupling of alkyl electrophiles with secondary and tertiary alkyl Grignard reagents. The method is distinguished by its broad substrate scope and high functional group tolerance. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9110 / 9113

页数：4

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