On the origin of leprosy

被引：292

作者：

Monot, M

Honoré, N

Garnier, T

Araoz, R

Coppée, JY

Lacroix, C

Sow, S

Spencer, JS

Truman, RW

Williams, DL

Gelber, R

Virmond, M

Flageul, B

Cho, SN

Ji, BH

Paniz-Mondolfi, A

Convit, J

Young, S

Fine, PE

Rasolofo, V

Brennan, PJ

Cole, ST ^{[1
]}

机构：

[1] Inst Pasteur, Unite Genet Mol Bacterienne, Paris, France

[2] Inst Pasteur, Genopole, PF2, Paris, France

[3] Ctr Natl Appui Lutte Malad, Bamako, Mali

[4] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

[5] Louisiana State Univ, BPHC, HRSA, DHHS,Natl Hansens Dis Program, Baton Rouge, LA 70894 USA

[6] Leonard Wood Mem Ctr Leprosy Res, Cebu, Philippines

[7] Inst Lauro de Souza Lima, Sao Paulo, Brazil

[8] Hop St Louis, Paris, France

[9] Yonsei Univ, Coll Med, Seoul, South Korea

[10] Univ Paris 06, Paris, France

[11] Inst Biomed, Caracas, Venezuela

[12] London Sch Hyg & Trop Med, London WC1, England

[13] Inst Pasteur Madagascar, Antananarivo, Madagascar

来源：

SCIENCE | 2005年 / 308卷 / 5724期

关键词：

D O I：

10.1126/science/1109759

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.

引用

页码：1040 / 1042

页数：3

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