Plasma and synovial fluid inflammatory cytokine profiles in primary knee osteoarthritis

被引：88

作者：

Mabey, Thomas ^{[1
]}

Honsawek, Sittisak ^{[1
,2
]}

Tanavalee, Aree ^{[2
]}

Yuktanandana, Pongsak ^{[2
]}

Wilairatana, Vajara ^{[2
]}

Poovorawan, Yong ^{[3
]}

机构：

[1] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Dept Biochem, Fac Med,Thai Red Cross Soc, Bangkok, Thailand

[2] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Dept Orthopaed, Vinai Parkpian Orthopaed Res Ctr,Fac Med,Thai Red, Bangkok, Thailand

[3] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Dept Pediat,Fac Med,Ctr Excellence Clin Virol, Bangkok, Thailand

来源：

BIOMARKERS | 2016年 / 21卷 / 07期

关键词：

Anti-inflammatory; cytokines; osteoarthritis; plasma; proinflammatory; synovial fluid; INTERLEUKIN-4; RECEPTOR; SERUM;

D O I：

10.3109/1354750X.2016.1171907

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Objective: The objective of this study is to compare inflammatory cytokine levels in primary knee osteoarthritis (OA) patients and healthy controls. Methods: A total of 32 knee OA patients and 14 healthy controls were enrolled. A multiplex immunoassay was utilized for 10 cytokines in plasma and synovial fluid. Results: Plasma IL-2, IL-4, and IL-6 concentrations were significantly greater in knee OA patients than controls. Moreover, both plasma IL-4 and IL-6 were positively correlated with the radiographic severity of knee OA. Conclusions: Plasma IL-4 and IL-6 may serve as biomarkers reflecting the severity of OA.

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收藏

页码：639 / 644

页数：6

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