Effects of physical stimulation on chondrogenesis in vitro

被引：25

作者：

Mizuno, S

Ushida, T

Tateishi, T

Glowacki, J

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Orthoped Surg, Boston, MA 02115 USA

[2] Minist Int Trade & Ind, Agcy Ind Sci & Technol, Natl Inst Interdisciplinary Res, 3D Tissue Engn Grp, Tsukuba, Ibaraki 305, Japan

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Dent Med, Skeletal Biol Res Ctr, Boston, MA 02114 USA

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 1998年 / 6卷 / 04期

关键词：

chondrogenesis; cartilage; stimuli;

D O I：

10.1016/S0928-4931(98)00068-X

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In cartilage, chondrocytes are embedded in an extracellular matrix composed of water, soluble constituents, and insoluble polymers. The physical stimulation of weight-bearing is known to influence the development, maturation, and degeneration of cartilage. The effects of osmotic and swelling pressure, oxygen tension, and hydrostatic pressure as well as interstitial fluid flow are modulated by compression of the solid cartilage matrix. These physical and physicochemical stimuli may be useful to engineer replacement cartilage. We summarize the effects of these stimuli and propose new methods to apply them. Our novel three-dimensional pressure/perfusion culture system has potential for improving in vitro engineering of autogenous cartilage. (C) 1998 Published by Elsevier Science S.A. All rights reserved.

引用

页码：301 / 306

页数：6

共 67 条

[1] STAGE-RELATED CAPACITY FOR LIMB CHONDROGENESIS IN CELL-CULTURE [J].