Regulation of monoamine oxidase a by circadian-clock components implies clock influence on mood

被引:309
作者
Hampp, Gabriele [1 ]
Ripperger, Juergen A. [1 ]
Houben, Thijs [2 ]
Schmutz, Isabelle [1 ]
Blex, Christian [3 ]
Perreau-Lenz, Stephanie [4 ]
Brunk, Irene
Spanagel, Rainer [4 ]
Ahnert-Hilger, Gudrun [3 ]
Meijer, Johanna H. [2 ]
Albrecht, Urs [1 ]
机构
[1] Univ Fribourg, Dept Med, Div Biochem, CH-1700 Fribourg, Switzerland
[2] Leiden Univ, Med Ctr, Dept Mol Cell Biol, Neurophysiol Lab, NL-2300 RC Leiden, Netherlands
[3] Charite, Ctr Anat, AG Funct Cell Biol, D-10115 Berlin, Germany
[4] Cent Inst Mental Hlth, Dept Psychopharmacol, D-68159 Mannheim, Germany
关键词
D O I
10.1016/j.cub.2008.04.012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The circadian clock has been implicated in addiction and several forms of depression [1, 2], indicating interactions between the circadian and the reward systems in the brain [3-5]. Rewards such as food, sex, and drugs influence this system in part by modulating dopamine neurotransmission in the mesolimbic dopamine reward circuit, including the ventral tegmental area (VTA) and the ventral striatum (NAc). Hence, changes in dopamine levels in these brain areas are proposed to influence mood in humans and mice [6-10]. To establish a molecular link between the circadian-clock mechanism and dopamine metabolism, we analyzed the murine promoters of genes encoding key enzymes important in dopamine metabolism. We find that transcription of the monoamine oxidase A (Maoa) promoter is regulated by the clock components BMAL1, NPAS2, and PER2. A mutation in the clock gene Per2 in mice leads to reduced expression and activity of MAOA in the mesolimbic dopaminergic system. Furthermore, we observe increased levels of dopamine and altered neuronal activity in the striatum, and these results probably lead to behavioral alterations observed in Per2 mutant mice in despair-based tests. These findings suggest a role of circadian-clock components in dopamine metabolism highlighting a role of the clock in regulating mood-related behaviors.
引用
收藏
页码:678 / 683
页数:6
相关论文
共 23 条
  • [1] Cocaine sensitization and reward are under the influence of circadian genes and rhythm
    Abarca, C
    Albrecht, U
    Spanagel, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) : 9026 - 9030
  • [2] Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster
    Andretic, R
    Hirsh, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) : 1873 - 1878
  • [3] Requirement of circadian genes for cocaine sensitization in Drosophila
    Andretic, R
    Chaney, S
    Hirsh, J
    [J]. SCIENCE, 1999, 285 (5430) : 1066 - 1068
  • [4] Characterization of cocaine self-administration and pharmacokinetics as a function of time of day in the rat
    Baird, TJ
    Gauvin, DV
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2000, 65 (02) : 289 - 299
  • [5] Resetting of circadian time peripheral tissues by glucocorticoid signaling
    Balsalobre, A
    Brown, SA
    Marcacci, L
    Tronche, F
    Kellendonk, C
    Reichardt, HM
    Schütz, G
    Schibler, U
    [J]. SCIENCE, 2000, 289 (5488) : 2344 - 2347
  • [6] AGGRESSIVE-BEHAVIOR AND ALTERED AMOUNTS OF BRAIN-SEROTONIN AND NOREPINEPHRINE IN MICE LACKING MAOA
    CASES, O
    SEIF, I
    GRIMSBY, J
    GASPAR, P
    CHEN, K
    POURNIN, S
    MULLER, U
    AGUET, M
    BABINET, C
    SHIH, JC
    DEMAEYER, E
    [J]. SCIENCE, 1995, 268 (5218) : 1763 - 1766
  • [7] CASTAGNE V, 2007, CURRENT PROTOCOLS S, V38
  • [8] Striatal dopamine metabolism in monoamine oxidase B-deficient mice: A brain dialysis study
    Fornai, F
    Chen, K
    Giorgi, FS
    Gesi, M
    Alessandri, MG
    Shih, JC
    [J]. JOURNAL OF NEUROCHEMISTRY, 1999, 73 (06) : 2434 - 2440
  • [9] Hsu YPP, 1996, AM J PSYCHIAT, V153, P1209
  • [10] Reciprocal regulation of haem biosynthesis and the circadian clock in mammals
    Kaasik, K
    Lee, CC
    [J]. NATURE, 2004, 430 (6998) : 467 - 471