Studies on the synthesis of the core structures of the antitumor agents neocarzinostatin, kedarcidin, C-1027 and maduropeptin

被引：63

作者：

Magnus, P

Carter, R

Davies, M

Elliott, J

Pitterna, T

机构：

[1] Department of Chemistry and Biochemistry, University of Texas at Austin, Austin

来源：

TETRAHEDRON | 1996年 / 52卷 / 18期

关键词：

D O I：

10.1016/0040-4020(96)00283-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bicyclo[7.3.0]dodecadiyne core structure of the antitumor agents neocarzinostatin, kedarcidin, C-1027 and maduropeptin can be readily constructed by an intramolecular aldol reaction to form the C-8/C-9 bond only if the C-6,7 triple bond is complexed as its eta(2)Co(2)(CO)(6)-acetylene adduct. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6283 / 6306

页数：24

共 66 条

[1]

BARNIER JP, 1973, TETRAHEDRON LETT, V14, P1747

[2]

BETRAND M, 1972, B CHIM SOC FR, P2775

[3] MODE OF REVERSIBLE BINDING OF NEOCARZINOSTATIN CHROMOPHORE TO DNA - EVIDENCE FOR BINDING VIA THE MINOR GROOVE [J].