PTEN: from pathology to biology

被引：280

作者：

Sulis, ML

Parsons, R ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Inst Canc Genet, New York, NY 10027 USA

[2] Columbia Univ, Div Pediat Oncol, Childrens Hosp, Herbert Irving Canc Ctr,Coll Phys & Surg, New York, NY USA

[3] Columbia Univ, Coll Phys & Surg, Dept Pathol, Herbert Irving Canc Ctr, New York, NY USA

[4] Columbia Univ, Coll Phys & Surg, Dept Med, Herbert Irving Canc Ctr, New York, NY USA

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(03)00175-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The PTEN tumour suppressor gene is mutated frequently in many malignancies and its importance in the development of cancer is probably underestimated. As the primary phosphatase of phosphatidlylinositol (3,4,5)-trisphosphate, PTEN has a central role in reigning in the phosphoinositide 3-kinase (PI 3-kinase) network to control cellular homeostasis. Cells that lack PTEN are unable to regulate the Ptdlns 3-kinase programme, which stimulates a variety of cellular phenotypes that favour oncogenesis. As well as the well-known role as tumour suppressor, recent studies show that PTEN is involved in the regulation of several basic cellular functions, such as cell migration, cell size, contractility of cardiac myocytes and chemotaxis. Here, we review the roles of PTEN in normal cellular functions and disease development.

引用

收藏

页码：478 / 483

页数：6

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