First tricyclic oximino derivatives as 5-HT3 ligands

被引：8

作者：

Baglin, I

Daveu, C

Lancelot, JC

Bureau, R

Dauphin, F

Pfeiffer, B

Renard, P

Delagrange, P

Rault, S

机构：

[1] Univ Caen, Ctr Etud & Rech Med Normandie, F-14032 Caen, France

[2] Univ Caen, Ctr Cyceron, CNRS, UMR 6551, F-14074 Caen, France

[3] ADIR & CIE, F-92415 Courbevoie, France

[4] Inst Rech Int Servier, F-92415 Courbevoie, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00691-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design and synthesis of a new type of 5-HT3 ligand with subnanomolar affinity are described. The O-dialkyl-aminoethyloximinothienopyrrolizine structure was deduced from molecular modeling studies by replacement of an amidine moiety by an oximino one. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：453 / 457

页数：5

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