Humoral immune responses of Africans to cysteine protease-related antigens of Plasmodium falciparum

被引：4

作者：

Gor, DO ^{[1
]}

Rosenthal, PJ ^{[1
]}

机构：

[1] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1998年 / 178卷 / 01期

关键词：

D O I：

10.1086/517455

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Plasmodium falciparum serine repeat antigen (SERA) and serine repeat protein homologue (SERPH) contain highly conserved domains that appear to encode cysteine proteases or related proteins. Humoral immune responses against the protease domains of SERA and SERPH were evaluated. Malaria-immune Africans, but not nonimmune controls, demonstrated potent humoral responses against the protease domains. As the SERA and SERPH protease domains are likely accessible to circulating antibody, these results suggest that humoral responses to the domains may contribute to antimalarial immunity.

引用

页码：285 / 288

页数：4

共 15 条

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