Influence of sol and stage of spinnability on in vitro bioactivity and dissolution of sol-gel-derived SiO2 fibers

被引:40
作者
Peltola, T
Jokinen, M
Veittola, S
Rahiala, H
Yli-Urpo, A
机构
[1] Univ Turku, Inst Dent, FIN-20520 Turku, Finland
[2] Abo Akad Univ, Dept Chem Phys, FIN-20500 Turku, Finland
[3] Tampere Univ Technol, FIN-33101 Tampere, Finland
关键词
silica sol; dry spinning; green state fiber; aging of fiber; HCA formation;
D O I
10.1016/S0142-9612(00)00219-2
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The ability of the sol-gel-derived green state silica fibers to induce the formation of bone-like calcium phosphate (HCA) on their surfaces has not been studied earlier. Bioactive silica fibers provide alternatives for the design of novel products, e.g., as implants used in tissue guiding or bone repairs. In this study, dry spinning was used to prepare the sol-gel fibers. Different fibers with different bulk structures were prepared by changing the: composition and controlling the stage of spinnability. Additionally, the influence of the aging time of the fibers on the bulk structure of the samples was investigated. Furthermore. the ability to form calcium phosphate was investigated in vitro in the simulated body fluid (SBF). Transmission electron microscopy was used to illustrate the bulk structure of the green state fibers and scanning electron microscopy to illustrate the formed calcium phosphate layer on the fibers. The fibers were additionally characterized by measuring the dissolution of the silica in the SBF. In vitro bioactive silica fibers were successfully prepared. The calcium phosphate layer was formed within 1-5 days in the best case. The structural stability and the in vitro bioactivity varied with the aging time expect in one case where practically stable fibers could be prepared. The concentration of silica released in the SBF had no direct connection with the HCA formation. The silica-rich gel layer was not observed on the fibers, but the structure of the fibers was suggested to have an important role in the HCA formation. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:589 / 598
页数:10
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