Serum leptin and weight loss in severely obese patients undergoing biliopancreatic diversion

被引：17

作者：

Adami, GF

Cordera, R

Campostano, A

Bressani, A

Cella, F

Scopinaro, N

机构：

[1] Univ Genoa, Fac Med, Ist Clin Chirurg, I-16132 Genoa, Italy

[2] Univ Genoa, Dipartimento Sci Endocrine & Metab, I-16132 Genoa, Italy

[3] Osped San Martino Genova, Div Med 1, Genova, Italy

来源：

INTERNATIONAL JOURNAL OF OBESITY | 1998年 / 22卷 / 08期

关键词：

leptin; obesity; obesity surgery;

D O I：

10.1038/sj.ijo.0800665

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: To evaluate the influence of body fat and food intake on serum leptin concentration. DESIGN: Longitudinal study of a group of obese patients prior to and at, long term follow-up, after biliopancreatic diversion (BPD), when body weight was steadily reduced and food consumption was similar to or greater than preoperatively. RESULTS: In obese patients, very high serum leptin concentrations were found. Following the operation, with the body weight stable and normalized, a sharp fall of serum leptin concentration had occurred, with values returned to normal range. CONCLUSION: The changes in serum leptin concentration observed in the long term after weight loss are substantially accounted for by the loss of body fat and appear unrelated to the reduction of oral food intake.

引用

收藏

页码：822 / 824

页数：3

相关论文

共 14 条

[1] Leptin: The tale of an obesity gene [J].

Caro, JF ;

Sinha, MK ;

Kolaczynski, JW ;

Zhang, PL ;

Considine, RV .

DIABETES, 1996, 45 (11) :1455-1462

[2] Serum immunoreactive leptin concentrations in normal-weight and obese humans [J].

Considine, RV ;

Sinha, MK ;

Heiman, ML ;

Kriauciunas, A ;

Stephens, TW ;

Nyce, MR ;

Ohannesian, JP ;

Marco, CC ;

McKee, LJ ;

Bauer, TL ;

Caro, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :292-295

[3] Plasma leptin and insulin relationships in obese and nonobese humans [J].

DagogoJack, S ;

Fanelli, C ;

Paramore, D ;

Brothers, J ;

Landt, M .

DIABETES, 1996, 45 (05) :695-698

[4] LEPTIN LEVELS REFLECT BODY LIPID-CONTENT IN MICE - EVIDENCE FOR DIET-INDUCED RESISTANCE TO LEPTIN ACTION [J].

FREDERICH, RC ;

HAMANN, A ;

ANDERSON, S ;

LOLLMANN, B ;

LOWELL, BB ;

FLIER, JS .

NATURE MEDICINE, 1995, 1 (12) :1311-1314

[5] Serum leptin and weight reduction in female obesity [J].

Geldszus, R ;

Mayr, B ;

Horn, R ;

Geisthovel, F ;

vonzurMuhlen, A ;

Brabant, G .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1996, 135 (06) :659-662

[6] Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss [J].

Havel, PJ ;

KasimKarakas, S ;

Mueller, W ;

Johnson, PR ;

Gingerich, RL ;

Stern, JS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (12) :4406-4413

[7] LEPTIN LEVELS IN HUMAN AND RODENT - MEASUREMENT OF PLASMA LEPTIN AND OB RNA IN OBESE AND WEIGHT-REDUCED SUBJECTS [J].

MAFFEI, M ;

HALAAS, J ;

RAVUSSIN, E ;

PRATLEY, RE ;

LEE, GH ;

ZHANG, Y ;

FEI, H ;

KIM, S ;

LALLONE, R ;

RANGANATHAN, S ;

KERN, PA ;

FRIEDMAN, JM .

NATURE MEDICINE, 1995, 1 (11) :1155-1161

[8] Serum leptin in relation to resting energy expenditure and fuel metabolism in obese subjects [J].

Niskanen, L ;

Haffner, S ;

Karhunen, LJ ;

Turpeinen, AK ;

Miettinen, H ;

Uusitupa, MIJ .

INTERNATIONAL JOURNAL OF OBESITY, 1997, 21 (04) :309-313

[9] EFFECTS OF THE OBESE GENE-PRODUCT ON BODY-WEIGHT REGULATION IN OB/OB MICE [J].

PELLEYMOUNTER, MA ;

CULLEN, MJ ;

BAKER, MB ;

HECHT, R ;

WINTERS, D ;

BOONE, T ;

COLLINS, F .

SCIENCE, 1995, 269 (5223) :540-543

[10] RECOMBINANT OB-GENE PRODUCT REDUCES FOOD-INTAKE IN FASTED MICE [J].

RENTSCH, J ;

LEVENS, N ;

CHIESI, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 214 (01) :131-136