Mineralocorticoid resistance

被引：48

作者：

Geller, DS ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Nephrol Sect, New Haven, CT 06520 USA

来源：

CLINICAL ENDOCRINOLOGY | 2005年 / 62卷 / 05期

关键词：

D O I：

10.1111/j.1365-2265.2005.02229.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mineralocorticoid aldosterone plays a crucial role in regulation of volume and electrolyte homeostasis. In recent years there has been considerable progress in deciphering the role of aldosterone in human physiology by the study of monogenic disorders exhibiting mineralocorticoid resistance. Although these disorders are rare, the elucidation of their molecular basis has yielded many insights into aldosterone biology that are proving relevant to the care of patients with a wide variety of cardiovascular diseases. Recent advances in understanding the molecular basis of syndromes of mineralocorticoid resistance are reviewed with a view towards an improved understanding of the role of aldosterone in renal sodium transport and its relationship to cardiovascular disease.

引用

页码：513 / 520

页数：8

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