Fimbriae-mediated host-pathogen cross-talk

被引:42
作者
Abraham, SN
Jonsson, AB
Normark, S
机构
[1] Duke Univ, Med Ctr, Dept Pathol & Microbiol, Durham, NC 27710 USA
[2] Karolinska Inst, Dept Bacteriol, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden
关键词
D O I
10.1016/S1369-5274(98)80145-8
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Recent studies show that the coupling of fimbrial adhesins of uropathogenic Escherichia coli and pathogenic Neisseria species to their complementary receptors on host cells is a dynamic event, involving specific signaling to the bacteria as well as to the host cell. These studies have unveiled intriguing and novel mechanisms by which bacteria utilize their fimbriae to promote virulence at the mucosal surface and in deeper tissue.
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页码:75 / 81
页数:7
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