Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? Commentary

被引：110

作者：

Reusch, JEB

机构：

[1] Vet Affairs Med Ctr, Endocrinol Sect 111H, Denver, CO 80220 USA

[2] Univ Colorado, Hlth Sci Ctr, Div Endocrinol Diabet & Metab, Dept Med, Denver, CO USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 07期

关键词：

D O I：

10.1172/JCI200319902

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential therapeutic roles in the prevention of diabetic complications.

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收藏

页码：986 / 988

页数：3

相关论文

共 32 条

[1] Relationship between obesity, insulin resistance, and coronary heart disease risk [J].

Abbasi, F ;

Brown, BW ;

Lamendola, C ;

McLaughlin, T ;

Reaven, GM .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (05) :937-943

[2] The sensory symptoms of diabetic polyneuropathy are improved with α-lipoic acid -: The SYDNEY trial [J].

Ametov, AS ;

Barinov, A ;

Dyck, PJ ;

Hermann, R ;

Kozlova, N ;

Litchy, WJ ;

Low, PA ;

Nehrdich, D ;

Novosadova, M ;

O'Brien, PC ;

Reljanovic, M ;

Samigullin, R ;

Schuette, K ;

Strokov, I ;

Tritschler, H ;

Wessel, K ;

Yakhno, N ;

Ziegler, D .

DIABETES CARE, 2003, 26 (03) :770-776

[3] Estimated number of adults with prediabetes in the US in 2000 - Opportunities for prevention [J].

Benjamin, SM ;

Valdez, R ;

Geiss, LS ;

Rolka, DB ;

Narayan, KMV .

DIABETES CARE, 2003, 26 (03) :645-649

[4] Projection of diabetes burden through 2050 - Impact of changing demography and disease prevalence in the US [J].

Boyle, JP ;

Honeycutt, AA ;

Narayan, KMV ;

Hoerger, TJ ;

Geiss, LS ;

Chen, H ;

Thompson, TJ .

DIABETES CARE, 2001, 24 (11) :1936-1940

[5] Biochemistry and molecular cell biology of diabetic complications [J].

Brownlee, M .

NATURE, 2001, 414 (6865) :813-820

[6]

Collins R, 2003, LANCET, V361, P2005

[7] POSTCHALLENGE GLUCOSE-CONCENTRATION AND CORONARY HEART-DISEASE IN MEN OF JAPANESE ANCESTRY - HONOLULU HEART PROGRAM [J].

DONAHUE, RP ;

ABBOTT, RD ;

REED, DM ;

YANO, K .

DIABETES, 1987, 36 (06) :689-692

[8]

Du XL, 2003, J CLIN INVEST, V112, P1049, DOI 10.1172/JCI200318127

[9]

Evans J L, 2000, Diabetes Technol Ther, V2, P401, DOI 10.1089/15209150050194279

[10]

Gerstein HC, 2000, LANCET, V355, P253

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