Photochemical desulfurization of L-cysteine derivatives

被引：26

作者：

González, A ^{[1
]}

Valencia, G

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

[2] CSIC, CID, Unit Glycoconjugate Chem, ES-08034 Barcelona, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 16期

关键词：

D O I：

10.1016/S0957-4166(98)00295-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Thiol groups can be reductively eliminated at room temperature by a photochemical method which make:; use of triethylboron, triethylphosphite and visible light. Thus, after treating L-Cys 1a, D-Pen 1b, L-Cys-OMe 1c and glutathione (gamma-L-Glu-L-Cys-Gly) 3, the corresponding desulfurized compounds L-Ala 2a, D-Val 2b, L-Ala-OMe 2e and gamma-L-Glu-L-Ala-Gly 4, respectively, are prepared in high yields and with retention of configuration. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2761 / 2764

页数：4

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