BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability
被引:83
作者:
Aly, Amal
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机构:
UMDNJ, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USAUMDNJ, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA
Aly, Amal
[1
]
Ganesan, Shridar
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UMDNJ, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USAUMDNJ, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA
Ganesan, Shridar
[1
]
机构:
[1] UMDNJ, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA
BRCA1 plays a critical role in the regulation of homologous recombination (HR)-mediated DNA double-strand break repair. BRCA1-deficient cancers have evolved to tolerate loss of BRCA1 function. This renders them vulnerable to agents, such as PARP inhibitors, that are conditionally 'synthetic lethal' with their underlying repair defect. Recent studies demonstrate that BRCA1-deficient cells may acquire resistance to these agents by partially correcting their defect in HR-mediated repair, either through reversion mutations in BRCA1 or through 'synthetic viable' loss of 53BP1. These findings and their clinical implications will be reviewed in this article.
机构:
London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Ahel, Dragana
;
Horejsi, Zuzana
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机构:
London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Horejsi, Zuzana
;
Wiechens, Nicola
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h-index: 0
机构:
Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, ScotlandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Wiechens, Nicola
;
Polo, Sophie E.
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h-index: 0
机构:
Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Polo, Sophie E.
;
Garcia-Wilson, Elisa
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h-index: 0
机构:
Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, ScotlandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Garcia-Wilson, Elisa
;
Ahel, Ivan
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h-index: 0
机构:
Univ Manchester, Paterson Inst Canc Res, Canc Res UK, Manchester M20 4BX, Lancs, England
London Res Inst, Genet Recombinat Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Ahel, Ivan
;
Flynn, Helen
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h-index: 0
机构:
London Res Inst, Prot Anal & Prote Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Flynn, Helen
;
Skehel, Mark
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h-index: 0
机构:
London Res Inst, Prot Anal & Prote Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Skehel, Mark
;
West, Stephen C.
论文数: 0引用数: 0
h-index: 0
机构:London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
West, Stephen C.
;
Jackson, Stephen P.
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h-index: 0
机构:
Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Jackson, Stephen P.
;
Owen-Hughes, Tom
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h-index: 0
机构:
Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, ScotlandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Owen-Hughes, Tom
;
Boulton, Simon J.
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h-index: 0
机构:
London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
机构:
Canc Res UK London Res Inst, Clare Hall Labs, Genet Recombinat Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Ahel, Ivan
;
Ahel, Dragana
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h-index: 0
机构:
Canc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Ahel, Dragana
;
Matsusaka, Takahiro
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h-index: 0
机构:
Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QR, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Matsusaka, Takahiro
;
Clark, Allison J.
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h-index: 0
机构:
Canc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Clark, Allison J.
;
Pines, Jonathon
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h-index: 0
机构:
Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QR, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Pines, Jonathon
;
Boulton, Simon J.
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h-index: 0
机构:
Canc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Boulton, Simon J.
;
West, Stephen C.
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h-index: 0
机构:
Canc Res UK London Res Inst, Clare Hall Labs, Genet Recombinat Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
机构:
Inst Canc Res, Chester Beatty Labs, Breakthrough Breast Canc Res Ctr, London SW3 6JB, EnglandInst Canc Res, Chester Beatty Labs, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England
机构:
Cedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Audeh, M. William
;
Carmichael, James
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h-index: 0
机构:
AstraZeneca, Macclesfield, Cheshire, EnglandCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Carmichael, James
;
Penson, Richard T.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Boston, MA 02114 USA
Dana Farber Canc Inst, Boston, MA 02115 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Penson, Richard T.
;
Friedlander, Michael
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h-index: 0
机构:
Prince Wales Canc Ctr, Sydney, NSW, AustraliaCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Friedlander, Michael
;
Powell, Bethan
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h-index: 0
机构:
Univ Calif San Francisco, San Francisco, CA 94143 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Powell, Bethan
;
Bell-McGuinn, Katherine M.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, New York, NY 10021 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Bell-McGuinn, Katherine M.
;
Scott, Clare
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h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
Royal Melbourne Hosp, Melbourne, Vic, AustraliaCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Scott, Clare
;
Weitzel, Jeffrey N.
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h-index: 0
机构:
City Hope Comprehens Canc Ctr, Duarte, CA USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Weitzel, Jeffrey N.
;
Oaknin, Ana
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h-index: 0
机构:
Hosp Gen Valle Hebron, Barcelona, SpainCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Oaknin, Ana
;
Loman, Niklas
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h-index: 0
机构:
Lund Univ, Skane Univ Hosp, Dept Oncol, Lund, SwedenCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Loman, Niklas
;
Lu, Karen
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h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Lu, Karen
;
Schmutzler, Rita K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cologne, Ctr Familial Breast, Cologne, Germany
Univ Cologne, Ovarian Canc, Cologne, Germany
Univ Cologne, Ctr Integrated Oncol, Cologne, GermanyCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Schmutzler, Rita K.
;
Matulonis, Ursula
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h-index: 0
机构:
Massachusetts Gen Hosp, Boston, MA 02114 USA
Dana Farber Canc Inst, Boston, MA 02115 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Matulonis, Ursula
;
Wickens, Mark
论文数: 0引用数: 0
h-index: 0
机构:
AstraZeneca, Macclesfield, Cheshire, EnglandCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Wickens, Mark
;
Tutt, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Breakthrough Breast Canc Res Unit, Sch Med, London WC2R 2LS, EnglandCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
机构:
London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Ahel, Dragana
;
Horejsi, Zuzana
论文数: 0引用数: 0
h-index: 0
机构:
London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Horejsi, Zuzana
;
Wiechens, Nicola
论文数: 0引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, ScotlandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Wiechens, Nicola
;
Polo, Sophie E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Polo, Sophie E.
;
Garcia-Wilson, Elisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, ScotlandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Garcia-Wilson, Elisa
;
Ahel, Ivan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Paterson Inst Canc Res, Canc Res UK, Manchester M20 4BX, Lancs, England
London Res Inst, Genet Recombinat Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Ahel, Ivan
;
Flynn, Helen
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h-index: 0
机构:
London Res Inst, Prot Anal & Prote Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Flynn, Helen
;
Skehel, Mark
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h-index: 0
机构:
London Res Inst, Prot Anal & Prote Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Skehel, Mark
;
West, Stephen C.
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机构:London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
West, Stephen C.
;
Jackson, Stephen P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Jackson, Stephen P.
;
Owen-Hughes, Tom
论文数: 0引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, ScotlandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Owen-Hughes, Tom
;
Boulton, Simon J.
论文数: 0引用数: 0
h-index: 0
机构:
London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandLondon Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
机构:
Canc Res UK London Res Inst, Clare Hall Labs, Genet Recombinat Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Ahel, Ivan
;
Ahel, Dragana
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Ahel, Dragana
;
Matsusaka, Takahiro
论文数: 0引用数: 0
h-index: 0
机构:
Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QR, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Matsusaka, Takahiro
;
Clark, Allison J.
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Clark, Allison J.
;
Pines, Jonathon
论文数: 0引用数: 0
h-index: 0
机构:
Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QR, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Pines, Jonathon
;
Boulton, Simon J.
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
Boulton, Simon J.
;
West, Stephen C.
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Clare Hall Labs, Genet Recombinat Lab, S Mimms EN6 3LD, Herts, EnglandCanc Res UK London Res Inst, Clare Hall Labs, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England
机构:
Inst Canc Res, Chester Beatty Labs, Breakthrough Breast Canc Res Ctr, London SW3 6JB, EnglandInst Canc Res, Chester Beatty Labs, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England
机构:
Cedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Audeh, M. William
;
Carmichael, James
论文数: 0引用数: 0
h-index: 0
机构:
AstraZeneca, Macclesfield, Cheshire, EnglandCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Carmichael, James
;
Penson, Richard T.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Boston, MA 02114 USA
Dana Farber Canc Inst, Boston, MA 02115 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Penson, Richard T.
;
Friedlander, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Prince Wales Canc Ctr, Sydney, NSW, AustraliaCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Friedlander, Michael
;
Powell, Bethan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, San Francisco, CA 94143 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Powell, Bethan
;
Bell-McGuinn, Katherine M.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, New York, NY 10021 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Bell-McGuinn, Katherine M.
;
Scott, Clare
论文数: 0引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
Royal Melbourne Hosp, Melbourne, Vic, AustraliaCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Scott, Clare
;
Weitzel, Jeffrey N.
论文数: 0引用数: 0
h-index: 0
机构:
City Hope Comprehens Canc Ctr, Duarte, CA USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Weitzel, Jeffrey N.
;
Oaknin, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Gen Valle Hebron, Barcelona, SpainCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Oaknin, Ana
;
Loman, Niklas
论文数: 0引用数: 0
h-index: 0
机构:
Lund Univ, Skane Univ Hosp, Dept Oncol, Lund, SwedenCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Loman, Niklas
;
Lu, Karen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Lu, Karen
;
Schmutzler, Rita K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cologne, Ctr Familial Breast, Cologne, Germany
Univ Cologne, Ovarian Canc, Cologne, Germany
Univ Cologne, Ctr Integrated Oncol, Cologne, GermanyCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Schmutzler, Rita K.
;
Matulonis, Ursula
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Boston, MA 02114 USA
Dana Farber Canc Inst, Boston, MA 02115 USACedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Matulonis, Ursula
;
Wickens, Mark
论文数: 0引用数: 0
h-index: 0
机构:
AstraZeneca, Macclesfield, Cheshire, EnglandCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
Wickens, Mark
;
Tutt, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Breakthrough Breast Canc Res Unit, Sch Med, London WC2R 2LS, EnglandCedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA