Dengue: a continuing global threat

被引：1340

作者：

Guzman, Maria G. ^{[2
]}

Halstead, Scott B. ^{[3
]}

Artsob, Harvey ^{[4
]}

Buchy, Philippe ^{[5
]}

Jeremy Farrar ^{[6
]}

Gubler, Duane J. ^{[7
]}

Hunsperger, Elizabeth ^{[8
]}

Kroeger, Axel ^{[1
]}

Margolis, Harold S. ^{[8
]}

Martinez, Eric ^{[2
]}

Nathan, Michael B. ^{[9
]}

Luis Pelegrino, Jose ^{[2
]}

Cameron Simmons ^{[6
]}

Yoksan, Sutee ^{[10
]}

Peeling, Rosanna W. ^{[1
]}

机构：

[1] WHO, UNICEF, UNDP, World Bank,WHO Special Programme Res & Training T, CH-1211 Geneva 27, Switzerland

[2] Inst Trop Med, Marianao 13, Ciucad Habana, Cuba

[3] Pediat Dengue Vaccine Initiat, Seoul 151600, South Korea

[4] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada

[5] Inst Pasteur Cambodia, Unit 5, Phnom Penh, Cambodia

[6] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam

[7] Duke NUS Grad Med Sch Singapore, Singapore 169857, Singapore

[8] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Infect Dis, San Juan, PR 00920 USA

[9] WHO, Dept Neglected Trop Dis, CH-1211 Geneva, Switzerland

[10] Mahidol Univ, Inst Sci & Technol Dev, Ctr Vaccine Dev, Salaya 73170, Nakhon Pathom, Thailand

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年

基金：

英国惠康基金;

关键词：

PLAQUE-REDUCTION NEUTRALIZATION; LINKED-IMMUNOSORBENT-ASSAY; NONSTRUCTURAL PROTEIN NS1; POLYMERASE CHAIN-REACTION; TYPE-4 VACCINE CANDIDATE; ORIGINAL ANTIGENIC SIN; IMMUNOGLOBULIN-M IGM; T-CELL RESPONSES; HEMORRHAGIC-FEVER; VIRUS-INFECTION;

D O I：

10.1038/nrmicro2460

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue fever and dengue haemorrhagic fever are important arthropod-brone viral diseases. Each year, there are similar to 50 million dengue infections and similar to 500,000 individuals are hospitalized with dengue haemorrhagic fever, mainly in Southeast Asia, the Pacific and the Americas. Illness is produced by any of the four dengue virus serotypes. A global strategy aimed at increasing the capacity for surveillance and outbreak response, changing behaviours and reducing the disease burden using integrated vector management in conjunction with early and accurate diagnosis has been advocated. Antiviral drugs and vaccines that are currently under development could also make an important contribution to dengue control in the future.

引用

页码：S7 / S16

页数：10

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