Three-component enantioselective synthesis of propargylamines through Zr-catalyzed additions of alkyl zinc reagents to alkynylimines

被引：129

作者：

Akullian, LC ^{[1
]}

Snapper, ML ^{[1
]}

Hoveyda, AH ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 35期

关键词：

alkyl zinc reagents; asymmetric catalysis; enantioselectivity; propargylamines; zirconium;

D O I：

10.1002/anie.200352081

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Readily available amino acid based chiral ligands are used in a three-component Zr-catalyzed enantioselective synthesis of propargylamines (see schemes). The reaction affords important enantiomerically enriched building blocks that are not conveniently accessible by alternative catalytic methods.

引用

页码：4244 / 4247

页数：4

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