Correction of the anemia of epidermolysis bullosa with intravenous iron and erythropoietin

Severe forms of epidermolysis bullosa result in a transfusion-dependent chronic anemia and are fatal. The cause of the anemia is unknown. We evaluated five children whose anemia failed to respond to oral iron but who became transfusion independent after treatment with intravenous-iron and human recombinant erythropoietin.