Topical application of ionic polymers affects skin permeability barrier homeostasis

被引：10

作者：

Denda, M

Nakanishi, K

Kumazawa, N

机构：

[1] Shiseido Res Ctr, Kanazawa Ku, Yokohama, Kanagawa 2368643, Japan

[2] Kyoto Univ, Fac Engn, Kyoto, Japan

[3] Ibaraki Univ, Fac Engn, Mito, Ibaraki, Japan

来源：

SKIN PHARMACOLOGY AND PHYSIOLOGY | 2005年 / 18卷 / 01期

关键词：

electric double layer; epidermis; ion-exchange resin; stratum corneum;

D O I：

10.1159/000081684

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We previously demonstrated that the external electric potential affected skin barrier homeostasis. On the other hand, topical application of an ionic polymer formed a diffusion electric double layer on the surface of the skin. Thus, we evaluated effects of topical application of ionic polymers on the damaged skin barrier. Application of a nonionic polymer did not affect barrier recovery. Application of sodium salts of anionic polymers accelerated barrier recovery, while that of cationic polymers delayed it. Topical application of a sodium-exchange resin accelerated barrier recovery, but application of a calcium-exchange resin had no effect even when the resins had the same structure. Application of a chloride-exchange resin delayed barrier recovery. Topical application of ionic polymers influenced skin barrier homeostasis.

引用

收藏

页码：36 / 41

页数：6

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