Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and the lacZ gene in transgenic rodents

被引：27

作者：

Cariello, NF

Douglas, GR

Soussi, T

机构：

[1] DEPT HLTH & WELF,CTR ENVIRONM HLTH,MUTAGENESIS SECT,OTTAWA,ON K1A 0L2,CANADA

[2] CTR MOLEC GENET,INSERM,U301,PARIS,FRANCE

来源：

NUCLEIC ACIDS RESEARCH | 1996年 / 24卷 / 01期

关键词：

D O I：

10.1093/nar/24.1.119

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have created databases and software applications for the analysis of DNA mutations in the human p53 gene, the human hprt gene and the rodent transgenic lacZlocus. The databases themselves are stand-alone dBase files and the software for analysis of the databases runs on IBM-compatible computers. The software created for these databases permits filtering, ordering, report generation and display of information in the database, In addition, a significant number of routines have been developed for the analysis of single base substitutions, One method of obtaining the databases and software is via the World Wide Web (WWW), Open home page http://sunsite.unc.edu/dnam/mainpage.html with a WWW browser. Alternatively, the databases and programs are available via public ftp from anonymous@sunsite.unc.edu. There is no password required to enter the system. The databases and software are found in subdirectory pub/academic/biology/dna-mutations. Two other programs are available at the WWW site, a program for comparison of mutational spectra and a program for entry of mutational data into a relational database.

引用

页码：119 / 120

页数：2

共 14 条

[1] ALTERATIONS OF THE HPRT GENE IN HUMAN INVIVO-DERIVED 6-THIOGUANINE-RESISTANT LYMPHOCYTES-T [J].