The leading role of membrane Ca2+-ATPase in recovery of Ca2+ homeostasis after glutamate shock

被引：8

作者：

Storozhevykh, TP

Pinelis, VG

Vinskaya, NP

Surin, AM

Khodorov, BI

机构：

[1] Russian Acad Med Sci, Res Ctr Children Hlth, Lab Membranol, Moscow, Russia

[2] Russian Acad Med Sci, Inst Gen Pathol & Pathol Physiol, Moscow 125315, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 02期

关键词：

neuron; glutamate; neurotoxicity; Ca2+-ATPase; Na+/Ca2+-exchange;

D O I：

10.1023/A:1023811613109

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Combined blockade of Na+/Ca2+ exchange, Ca2+ uptake by mitochondria and endoplasmic reticulum usually does not prevent recovery of the basal level of intracellular Ca2+ after 1-min action of glutamate (100 muM) or K+ (50 mM). However, replacement of Ca2+ with Ba2+, which cannot be transported by Ca2+-ATPase, considerably delayed the decrease in intracellular Ba2+ after its rise caused by glutamate or potassium application in all examined cells, which attest to an important role of Ca2+-ATPase in Ca2+ extrusion after the action of glutamate or K+.

引用

收藏

页码：139 / 142

页数：4

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