Is the regulation of galactose 1-phosphate tuned against gene expression noise?

被引：9

作者：

de Atauri, P ^{[1
]}

Orrell, D ^{[1
]}

Ramsey, S ^{[1
]}

Bolouri, H ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98103 USA

来源：

BIOCHEMICAL JOURNAL | 2005年 / 387卷

关键词：

galactose-1-phosphate uridylyltransferase; galactose uptake; gene expression; metabolic pathway; noise transmission; Saccharomyces cerevisiae;

D O I：

10.1042/BJ20041001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The average number of mRNA molecules per active gene in yeast can be remarkably low. Consequently, the relative number of copies of each transcript per cell can vary greatly from moment to moment. When these transcripts are encoding metabolic enzymes, how do the resulting variations in enzyme concentrations affect the regulation of metabolic intermediates? Using a kinetic model of galactose utilization in yeast, we analysed the transmission of noise from transcription and translation on metabolic intermediate regulation. In particular, the effect of the kinetic properties of the galactose-1-phosphate uridylyltransferase reaction on the transmission of noise was analysed.

引用

页码：77 / 84

页数：8

共 51 条

[1] Robustness in bacterial chemotaxis [J].