Linkage disequilibrium: Ancient history drives the new genetics

被引：35

作者：

Abecasis, GR ^{[1
]}

Ghosh, D ^{[1
]}

Nichols, TE ^{[1
]}

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA

来源：

HUMAN HEREDITY | 2005年 / 59卷 / 02期

关键词：

linkage disequilibrium; natural selection; association mapping; recombination rate;

D O I：

10.1159/000085226

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This brief review provides a summary of the biological causes of genetic association between tightly linked markers - termed linkage disequilibrium - and unlinked markers - termed population structure. We also review the utility of linkage disequilibrium data in gene mapping in isolated populations, in the estimation of recombination rates and in studying the history of particular alleles, including the detection of natural selection. We discuss current understanding of the extent and patterns of linkage disequilibrium in the genome, and its promise for genetic association studies in complex disease. Finally, we highlight the importance of using appropriate statistical procedures, such as the false discovery rate, to maximize the chances of success in large scale association studies. Copyright (c) 2005 S. Karger AG, Basel.

引用

页码：118 / 124

页数：7

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