Natural Innate and Adaptive Immunity to Cancer

被引：1523

作者：

Vesely, Matthew D. ^{[1
]}

Kershaw, Michael H. ^{[2
,3
,4
]}

Schreiber, Robert D. ^{[1
]}

Smyth, Mark J. ^{[2
,3
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3002, Australia

[3] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia

[4] Monash Univ, Dept Immunol, Melbourne, Vic 3168, Australia

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 | 2011年 / 29卷

关键词：

immunosurveillance; immunoediting; equilibrium; immunotherapy; inflammation; immunosuppression; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; APOPTOSIS-INDUCING LIGAND; ANTIGEN-LOSS VARIANTS; IFN-GAMMA; SUPPRESSOR-CELLS; IN-VIVO; MALIGNANT-MELANOMA; PROGNOSTIC VALUE; MICE DEFICIENT;

D O I：

10.1146/annurev-immunol-031210-101324

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system can identify and destroy nascent tumor cells in a process termed cancer immunosurveillance, which functions as an important defense against cancer. Recently, data obtained from numerous investigations in mouse models of cancer and in humans with cancer offer compelling evidence that particular innate and adaptive immune cell types, effector molecules, and pathways can sometimes collectively function as extrinsic tumor-suppressor mechanisms. However, the immune system can also promote tumor progression. Together, the dual host-protective and tumor-promoting actions of immunity are referred to as cancer immunoediting. In this review, we discuss the current experimental and human clinical data supporting a cancer immunoediting process that provide the fundamental basis for further study of immunity to cancer and for the rational design of immunotherapies against cancer.

引用

页码：235 / 271

页数：37

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