Comparison of efficacy, safety, and cost of low-molecular-weight heparin with continuous-infusion unfractionated heparin for initiation of anticoagulation after mechanical prosthetic valve implantation

被引：54

作者：

Fanikos, J

Tsilimingras, K

Kucher, N

Rosen, AB

Hieblinger, MD

Goldhaber, SZ

机构：

[1] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Ctr Clin Excellence, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2004年 / 93卷 / 02期

关键词：

D O I：

10.1016/j.amjcard.2003.09.054

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compared the efficacy, safety, and impact on postoperative hospital length of stay and inpatient hospital costs of low-molecular-weight heparin with that of unfractionated heparin as a "bridge" to achieving therapeutic levels of anticoagulation with warfarin in patients with newly implanted prosthetic heart valves. The patients who received low-molecular-weight heparin had a shorter length of stay and decreased postoperative costs compared with the control subjects receiving unfractionated heparin. (C) 2004 by Excerpta Medica, Inc.

引用

页码：247 / 250

页数：4

共 11 条

[1] Managing oral anticoagulant therapy [J].

Ansell, J ;

Hirsh, J ;

Dalen, J ;

Bussey, H ;

Anderson, D ;

Poller, L ;

Jacobson, A ;

Deykin, D ;

Matchar, D .

CHEST, 2001, 119 (01) :22S-38S

[2] Guidelines for the management of patients with valvular heart disease - Executive summary - A report of the American College of Cardiology American Heart Association task force on practice guidelines (committee on management of patients with valvular heart disease) [J].

Bonow, RO ;

Carabello, B ;

de Leon, AC ;

Edmunds, LH ;

Fedderly, BJ ;

Freed, MD ;

Gaasch, WH ;

McKay, CR ;

Nishimura, RA ;

O'Gara, PT ;

O'Rourke, RA ;

Rahimtoola, SH ;

Ritchie, JL ;

Cheitlin, MD ;

Eagle, KA ;

Gardner, TJ ;

Garson, A ;

Gibbons, RJ ;

Russell, RO ;

Ryan, TJ ;

Smith, SC .

CIRCULATION, 1998, 98 (18) :1949-1984

[3] Low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis - A meta-analysis of randomized, controlled trials [J].

Gould, MK ;

Dembitzer, AD ;

Doyle, RL ;

Hastie, TJ ;

Garber, AM .

ANNALS OF INTERNAL MEDICINE, 1999, 130 (10) :800-+

[4] Low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis - A cost-effectiveness analysis [J].

Gould, MK ;

Dembitzer, AD ;

Sanders, GD ;

Garber, AM .

ANNALS OF INTERNAL MEDICINE, 1999, 130 (10) :789-+

[5] Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home [J].

Koopman, MMW ;

Prandoni, P ;

Piovella, F ;

Ockelford, PA ;

Brandjes, DPM ;

vanderMeer, J ;

Gallus, AS ;

Simonneau, G ;

Chesterman, CH ;

Prins, MH ;

Bossuyt, PMM ;

deHaes, H ;

vandenBelt, AGM ;

Sagnard, L ;

DAzemar, P ;

Buller, HR .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (11) :682-687

[6] A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis [J].

Levine, M ;

Gent, M ;

Hirsh, J ;

Leclerc, J ;

Anderson, D ;

Weitz, J ;

Ginsberg, J ;

Turpie, AG ;

Demers, C ;

Kovacs, M ;

Geerts, W ;

Kassis, J ;

Desjardins, L ;

Cusson, J ;

Cruickshank, M ;

Powers, P ;

Brien, W ;

Haley, S ;

Willan, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (11) :677-681

[7] Low molecular weight heparin after mechanical heart valve replacement [J].

Montalescot, G ;

Polle, V ;

Collet, JP ;

Leprince, P ;

Bellanger, A ;

Gandjbakhch, I ;

Thomas, D .

CIRCULATION, 2000, 101 (10) :1083-1086

[8] Economic evaluation of outpatient treatment with low-molecular-weight heparin for proximal vein thrombosis [J].

O'Brien, B ;

Levine, M ;

Willan, A ;

Goeree, R ;

Haley, S ;

Blackhouse, G ;

Gent, M .

ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (19) :2298-2304

[9] Use of Enoxaparin for the chronically anticoagulated patient before and after procedures [J].

Spandorfer, JM ;

Lynch, S ;

Weitz, HH ;

Fertel, S ;

Merli, GJ .

AMERICAN JOURNAL OF CARDIOLOGY, 1999, 84 (04) :478-+

[10]

Tinmouth AH, 2001, ANN PHARMACOTHER, V35, P669

← 1 2 →